Insulin shock therapy combined with adrenal cortical extract in schizophrenia.
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Insulin shock therapy combined with adrenal cortical extract in schizophrenia.

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Published .
Written in English


Book details:

Edition Notes

Thesis (M.D.)--The Queens" University of Belfast, 1951.

The Physical Object
Pagination1 v
ID Numbers
Open LibraryOL21531704M

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In the psychiatrist Manfred Sakel of Vienna presented the first report of his work with insulin shock. Until the discovery of the tranquilizing drugs, variations of insulin-shock therapy (also called insulin-coma therapy) were commonly used in the treatment of schizophrenia and other psychotic conditions. With insulin-shock treatment, the patient is given increasingly large doses of insulin, which reduce .   Insulin shock therapy, perhaps more accurately known as insulin coma therapy, was a form of psychiatric treatment used to treat schizophrenia in the early 20th century. Psychiatrists of the era believed that states of physiological shock could help control the symptoms of mental illness. This therapy was usually used to induce physiological shock in the form of a hypoglycemic coma. Patients with schizophrenia and personality disorders were more likely to disclose their illicit drug consumption relative to patients suffering from mood disorders and alcohol dependence. Insulin shock therapy combined with adrenal cortical extract in schizophrenia. and cortical processing in schizophrenia, adding to the growing but mixed body of literature on emotion.

According to the study, published for the American Psychiatric Association by John R. Ross and Benjamin Malzberg, among cases of schizophrenia treated by insulin shock therapy, 11 % had prompt and total recovery, % were greatly improved and 26 % had some improvement.   Annane D, Cariou A, Maxime V, et al. Corticosteroid treatment and intensive insulin therapy for septic shock in adults: a randomized controlled trial. JAMA ; - Crossref. Almost one century after the original description of apoplexy of the adrenal glands in septic shock (), consensus is lacking on diagnostic criteria to define adrenal insufficiency in critical illness ().In unstressed subjects, adrenal insufficiency is defined by a cosyntropin-stimulated cortisol level less than 18–20 μg/dl (3, 4).In critical illness, the diagnostic criteria for adrenal.   Multiple RCTs have investigated the potential role for steroid therapy in patients with septic shock. The Annane Trial in with patients demonstrated a short-term mortality benefit with IV hydrocortisone and fludrocortisone among patients with evidence of adrenal insufficiency on ACTH stimulation testing.

Until the discovery of the tranquilizing drugs, variations of insulin-shock therapy (also called insulin-coma therapy) were commonly used in the treatment of schizophrenia and other psychotic conditions. With insulin-shock treatment, the patient is given increasingly large doses of insulin, which reduce the sugar. Insulin shock therapy, which is more correctly called insulin coma therapy, was a psychiatric treatment for schizophrenia used during the earlier part of the 20 th century. Psychiatrist during that period thought that a physiological shock can be used to control mental illness symptoms. Insulin shock therapy was frequently employed to cause physiological shock which is actually a hypoglycemic coma. Other types of shock therapy employed during that period were induced malarial fever . The method used and general observations made during insulin shock treatment of schizophrenia are discussed. From November, , to March, , 76 cases of schizophrenia were treated; 56 of them finished the complete course of therapy, the remaining 20 are either still taking the treatment or the treatment was interrupted for various reasons. A study before and after a series of insulin shock treatments in patients with schizophrenia was undertaken to determine the incidence of significant electrocardiographic alterations. It was concluded that this form of therapy is not associated with any cumulative injury to the myocardium which could be detected in the electrocardiogram.